Sensitivity and resistance to glucocorticoids
نویسندگان
چکیده
منابع مشابه
Sensitivity and resistance to glucocorticoids
In humans, glucocorticoids regulate a broad spectrum of physiologic functions essential for life and play an important role in the maintenance of basal and stress-related homeostasis. Approximately 20% of the genes expressed in human leukocytes are regulated positively or negatively by glucocorticoids. These steroids are involved in almost every cellular, molecular and physiologic network of th...
متن کاملSensitivity of bone to glucocorticoids.
Glucocorticoids are used widely in a range of medical specialities, but their main limitation is an adverse impact on bone. Although physicians are increasingly aware of these deleterious effects, the marked variation in susceptibility between individuals makes it difficult to predict who will develop skeletal complications with these drugs. Although the mechanisms underlying the adverse effect...
متن کاملAberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse.
The 37-kDa protein annexin 1 (Anx-1; lipocortin 1) has been implicated in the regulation of phagocytosis, cell signaling, and proliferation and is postulated to be a mediator of glucocorticoid action in inflammation and in the control of anterior pituitary hormone release. Here, we report that mice lacking the Anx-1 gene exhibit a complex phenotype that includes an altered expression of other a...
متن کاملDecreased pituitary sensitivity to glucocorticoids in endurance-trained men.
OBJECTIVE Muscular exercise induces hypothalamo-pituitary-adrenal (HPA) axis activation and when regularly repeated, as in endurance training, leads to HPA axis adaptation. To assess whether non-professional endurance-trained (ET) men with a substantial training load and no clinical or biological features of HPA axis overactivity can present subtle alterations of HPA axis sensitivity to glucoco...
متن کاملAltered peripheral sensitivity to glucocorticoids in primary open-angle glaucoma.
PURPOSE Increased levels of glucocorticoids are associated with raised intraocular pressure (IOP). The activity of glucocorticoids is regulated at a prereceptor level by 11beta-hydroxysteroid dehydrogenases (11beta-HSD). This study was an investigation of the central and peripheral sensitivity to glucocorticoids in patients with POAG or ocular hypertension (OHT) and the differential metabolism ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Rheumatology
سال: 2014
ISSN: 1546-0096
DOI: 10.1186/1546-0096-12-s1-i13